Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase

Bioorg Med Chem Lett. 2012 Jan 1;22(1):610-2. doi: 10.1016/j.bmcl.2011.10.072. Epub 2011 Oct 28.

Abstract

A new methylene-bridged bisflavonoid, methylenebissantin (1), and nine known compounds, including flavonoids (2-5), diterpenoids (6 and 7), and phenol derivatives (8-10) were isolated from the aerial parts of Dodonaea viscosa Jacq. The structure elucidation was based on spectroscopic data analyses. The isolated compounds were evaluated for the inhibition of Plasmodium falciparum enoyl-ACP reductase (PfENR). Methylenebissantin (1) exhibited a moderate inhibition (IC(50) 91.13 μM) against PfENR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical / methods*
  • Drug Design
  • Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / antagonists & inhibitors*
  • Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / chemistry
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Flavones / chemical synthesis*
  • Flavones / pharmacology
  • Flavonoids / chemistry
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy / methods
  • Models, Chemical
  • Plant Extracts / pharmacology*
  • Plants / metabolism*
  • Plasmodium falciparum / enzymology*
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Flavones
  • Flavonoids
  • Plant Extracts
  • methylenebissantin
  • Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)